Heiter, a former lecturer on traumatology, has a dark obsession with linking people mouth-to-anus, creating a grotesque, surgically-conjoined creature. He kidnaps the two American tourists and, through a series of gruesome and disturbing surgical procedures, joins them to a third victim, Cooke (Robert C. Kukes).

In conclusion, The Human Centipede LK21 is a film that defies categorization. This horrific masterpiece or odious aberration has ignited passionate debates among horror enthusiasts and sparked essential discussions about the role of violence in cinema.

The film's success can be measured by its influence on contemporary horror cinema, inspiring a new wave of filmmakers to push the boundaries of on-screen violence and transgression.

Detractors, on the other hand, condemn the film for its excessive and gratuitous violence, arguing that it serves no purpose other than to titillate and disturb. They accuse Tom Six of courting controversy and tastelessly exploiting his audience's sensibilities.