If you use an , you might unlock an item in-game that doesn't trigger the corresponding Steam achievement, leaving you stuck with a "broken" profile.

The Binding of Isaac: Repentance has no VAC or EAC anti-cheat. Edmund McMillen himself has acknowledged save editors as a tool for accessibility.

But with frequent updates (UPDs) to the game—especially after the major Co-op and balance patches in 2023-2024—keeping your save editor up-to-date is critical. An outdated editor can corrupt your repentance.save file.