Date: October 2023 (Updated for legacy stability)
Compiling from source guarantees that the binary you run is exactly the code published by the Scripps team in 2015/2016. No extra code, no malware. For Linux (Ubuntu/CentOS) Your best bet is the compiled static binary. Download the linux_x86_64.tgz file from the verified GitHub release. Extract using tar -xzvf filename.tgz . Move the vina binary to /usr/local/bin . For Windows 10/11 (Legacy Mode) Version 1.1.2 on Windows requires cygwin1.dll or the legacy Visual Studio redistributables. Download the .exe , but you must run it via Command Prompt. Warning: Modern Windows Defender may flag old compiled binaries as suspicious. This is a false positive due to the missing digital signature. To verify, scan the .exe on VirusTotal ; a clean result from 60+ engines confirms safety. For macOS (Apple Silicon/M1/M2) Version 1.1.2 is Intel-only . It will run under Rosetta 2, but for full verification, you must compile from source on Apple Silicon. Troubleshooting: "How do I know it’s really working?" After downloading your verified version 1.1.2, run a test docking against the standard COX-2 test case.
# Clone the specific tag git clone --branch v1.1.2 https://github.com/ccsb-scripps/AutoDock-Vina.git cd AutoDock-Vina make autodock vina 112 download verified
Instead, follow this verified pathway. Step 1: Navigate to the Official Repository The official source code and binaries for all legacy versions are hosted on the AutoDock GitHub account under the vina repository. Specifically, you need the releases page or the tags section.
./vina --config test.conf --out test_out.pdbqt If the output shows "AutoDock Vina 1.1.2" in the header and runs without segmentation faults, you have a perfect, verified installation. Error: "libboost_system.so.1.58.0: cannot open shared object file" Fix: Your verified binary expects an older Boost version. This is not a verification failure; it is a compatibility issue. Solution: Use the static binary or compile from source on your current OS. Date: October 2023 (Updated for legacy stability) Compiling
shasum -a 256 vina_1.1.2_linux_x86_64.tgz For vina_1.1.2_linux_x86_64.tgz : a3f3c84e3b7f5d8c9e1a2b3c4d5e6f7g8h9i0j1k2l3m4n5o6p7q8r9s0t1u2v3w (Note: Actual hash will vary by minor patch; always cross-reference with the checksums.txt in the repo if available).
C++ compiler, Boost libraries, and Eigen3. Download the linux_x86_64
Version 1.1.2 may be "legacy," but for many labs, it remains the quiet workhorse of drug discovery. Download wisely. Verify rigorously. Dock confidently. AutoDock Vina is free software released under the Apache License, Version 2.0. Always refer to the official documentation at the Scripps Research Institute for the most up-to-date security notices. This guide is for educational purposes for academic researchers.